| 1 | Centre de santé et de services sociaux du Granit (CSSSG) | Health and social services | Lac-Mégantic | 515 |
| 2 | Tafisa Canada | Manufacturer of particle boards and melamine | Lac-Mégantic | 350 |
| 3 | Masonite International | Doors and wood blinds, steel door components | Lac-Mégantic | 110 |
| 4 | Bestar inc. | Manufacturer of ready-to-assemble furniture | Lac-Mégantic | 142 |
| 5 | La Corporation Internationale Masonite – division Industries Manufacturières Mégantic | Manufacturer of plywood for doors and related products | Lac-Mégantic | 130 |
| 6 | Portes Lambton Inc. | Architectural and commercial doors | Lambton | 140 |
| 7 | Summum Granit | Granite and quartz products | St-Sébastien | 150 |
| 8 | Lacroix et Fils | Granite products for monuments and buildings | St-Sébastien | 140 |
| 9 | Fromagerie La Chaudière Inc. | Cheese factory | Lac-Mégantic | 110 |
| 10 | Polycor Granit Bussière Inc. | Granite slabs, tiles and other related products | St-Sébastien | 126 |
| 11 | Chemise Perfection Inc. | Manufacturer of shirts and pants for men and women | Courcelles | 220 |
| 12 | Marché Métro Mégantic | Grocery store | Lac-Mégantic | 105 |
| 13 | Les équipements Lapierre Inc. | Manufacturer of equipment for the maple syrup industry | St-Ludger | 104 |
| 14 | L.P. Royer Inc. & Tanart | Manufacturer of boots and leather shoes | Lac-Drolet | 100 |
| 15 | Société Coopérative Agricole | Animal feed, tools, other | Lac-Mégantic, Lambton, St-Sébastien | 86 |
| 16 | Attraction | Manufacturer of promotional clothing | Lac-Drolet | 85 |
| 17 | Services d’entretien domestique, Grand Ménage | Household maintenance | Lac-Mégantic | 70 |
| 18 | Maisons Usinex Inc. | Prefab houses | Milan | 65 |
| 19 | Lafontaine & Fils Inc. | Excavation work | Lac-Mégantic | 58 |
| 20 | Les Bois Poulin Inc. | Sawmill | Lac-Drolet | 52 |
